References・Publication

PuraMatrix™, which 3-D Matrix provides, is an excellent biocompatible material invented by Dr. Shuguang Zhang in the United States. Papers and documents associated with this material are as follows (partially extracted).

Clinical	1.	A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection-induced ulcer in the stomach. Gastrointestinal Endoscopy(Dec 2015)
Neuron	2.	Cultivation of human neural progenitor cells in a 3-dimensional self-assembling peptide hydrogel. Liedmann A, Rolfs A, Frech MJ. / J Vis Exp. 2012 Jan 11;(59):e3830. doi: 10.3791/3830. PMID: 22258286
Neuron	3.	Self-assembling peptide scaffolds in the clinic. Gelain F, Luo Z, Rioult M, Zhang S. / NPJ Regen Med. 2021 Feb 17;6(1):9. doi: 10.1038/s41536-020-00116-w. PMID: 33597509
Bone	4.	The enhancement of osteoblast growth and differentiation in vitro on a peptide hydrogel-polyHIPE polymer hybrid material. Biomaterials.2005
Cartilage	5.	Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair. Proceedings of the National Academy of Science (July 2002)
	6.	Evaluation of Medium supplemented with Insulin-Transferrin-Selenium for Culture of Primary Bovine Calf Chondrocytes in Three-Dimentional Hydrogel Scaffolds. Tissue Engineering(2005)
	7.	Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. Journal of Biomechanics (May 2004)
Liver	8.	Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. Gelain F, Bottai D, Vescovi A, Zhang S. / PLoS One. 2006 Dec 27;1(1):e119. doi: 10.1371/journal.pone.0000119. PMID: 17205123;
Vascular Endothelial Cell and Myocardium	9.	Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation. 2004 Aug 24;110(8):962-8.
	10.	Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells. Molecular Cardiology(2005)
	11.	Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials(2005)
	12.	The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. Biomaterials(2005)
Editorials	13.	Novel peptide-based biomaterial scaffolds for tissue engineering. TRENDS in Biotechnology(janu,2002)
	14.	Fabrication of novel biomaterials through molecular self-assembly. Nature biotechnology(oct,2003)
	15.	PuraMatrix™:Self-assembling peptide Nanofiber Scaffolds. Zhang et al.
Basic experiment	16.	The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis. Kakiuchi Y, Hirohashi N, Murakami-Murofushi K. / Biochem Biophys Res Commun. 2013 Apr 12;433(3):298-304. doi: 10.1016/j.bbrc.2013.02.105. Epub 2013 Mar 19. PMID: 23518074.

Overview

The self-assembling peptide, our core technology, was discovered by Dr. Shuguang Zhang of the Massachusetts Institute of Technology (MIT) in the United States in 1992. The first-generation self-assembling peptide has been produced as PuraMatrix™.

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PuraMatrix™
Self-Assembling

The self-assembling peptide we developed consists of an amphipathic peptide that forms nanofibers from the change in pH or the response to inorganic salts contained in solutions. At a macro level, gelatinization (self-assembling) occurs…

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Surfactant-Like Peptide

A surfactant-like peptide is a self-assembling peptide consisting of approximately 6-10 amino acid residues, forming nanomicelles and nanotubes with a particle diameter of about 50 to 100 nm in solutions.

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